A major goal of the authors continues to be to provide both medical and other students of the health sciences with a book that both describes the basics of biochemistry and is user-friendly and interesting. A second major ongoing goal is to reflect the most significant advances in biochemistry that are important to medicine. However, a third major goal of this edition was to achieve a substantial reduction in size, as feedback indicated that many readers prefer shorter texts.
A new chapter on amino acids and peptides, which emphasizes the manner in which the properties of biologic peptides derive from the individual amino acids of which they are comprised. A new chapter on the primary structure of proteins, which provide coverage of both classic and newly emerging proteomic and genomic methods for identifying proteins. A new section on the application of mass spectrometry to the analysis of protein structure has been added, including comments on the identification of covalent modifications. The chapter on the mechanisms of action of enzymes has been revised to provide a comprehensive description of the various physical mechanisms by which enzymes carry out their catalytic functions. The chapters on integration of metabolism, nutrition, digestion and absorption, and vitamins and minerals have been completely re-written.
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Book: Harper's Illustrated Biochemistry
Author: Robert K. Muray , Daryl K. Granner
The text is divided into two introductory chapters (“Biochemistry & Medicine” and “Water & pH”) followed by six main sections.
Section 1 deal with the structures and functions of proteins and enzymes, the workhorses of the body. Because almost all of the reactions in cells are catalyzed by enzymes, it is vital to understand the properties of enzymes before considering other topics.
Section 2 explains how various cellular reactions either utilize or release energy, and it traces the pathways by which carbohydrates and lipids are synthesized and degraded. It also describes the many functions of these two classes of molecules.
Section 3 deals with the amino acids and their many fates and also describes certain key features of protein catabolism.
Section 4 describes the structures and functions of the nucleotides and nucleic acids, and covers many major topics such as DNA replication and repair, RNA synthesis and modification, and protein synthesis. It also discusses new findings on how genes are regulated and presents the principles of recombinant DNA technology.
Section 5 deals with aspects of extracellular and intracellular communication. Topics covered include membrane structure and function, the molecular bases of the actions of hormones, and the key field of signal transduction.
Section 6 consists of discussions of eleven special topics: nutrition, digestion, and absorption; vitamins and minerals; intracellular traffic and sorting of proteins, glycoprotein, the extracellular matrix, muscle and the cytoskeleton, plasma proteins and immunoglobulin, homeostasis and thrombosis, red and white blood cells, the metabolism of xenobiotics and the Human Genome Project.
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